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3×4 Genetics is a clinically focused genetic testing platform that analyzes hundreds of variants across the pathways most relevant to functional medicine. Unlike consumer genetic tests (23andMe, Ancestry), which were built for ancestry and recreational discovery, 3×4 Genetics is built for clinical interpretation — specifically the pathways involved in nutrient processing, methylation, detoxification, neurotransmitter metabolism, and inflammatory response.
The test is done at home. Cheek swab. Results return in 4-6 weeks with a comprehensive Blueprint Report mapping your variants to actionable interventions.
The 3×4 framework groups variants into four metabolic categories — energy, defense, building, and communication — which makes the data clinically usable rather than overwhelming.
The Blueprint Report covers genetic pathways including:
MTHFR (C677T, A1298C), MTR, MTRR, BHMT, AHCY, CBS, COMT. The methyl-donor system that drives neurotransmitter synthesis, hormone metabolism, detoxification, and gene expression itself. Variants here change how you process folate, B12, and SAMe.
COMT (fast vs. slow), MAO-A, MAO-B, DBH, GAD1. How your body breaks down dopamine, norepinephrine, epinephrine, serotonin, and how excitatory vs. inhibitory your nervous system runs at baseline.
GST, NQO1, SOD2, CAT, NAT2, the cytochrome P450 family. How your liver processes hormones, medications, environmental toxins, and dietary compounds.
IL-6, TNF-α, NF-κB pathway variants. Your inflammatory tendency and how it interacts with stress, diet, and environment.
Vitamin D receptor, folate transport, B12 metabolism, omega-3 conversion, iron handling.
APOE (relevant for both cardiovascular risk and Alzheimer's risk), MTHFR's interaction with homocysteine, lipid metabolism variants.
Pathways relevant to common psychiatric medication metabolism (CYP2D6, CYP2C19, CYP3A4) — useful when coordinating with prescribers on medication optimization.
Genetic variants affect mental health through several converging pathways. Methylation variants like MTHFR can impair production of SAMe, the universal methyl donor required for serotonin and dopamine synthesis — and they’re surprisingly common. COMT variants affect how quickly your nervous system clears stress neurotransmitters; “slow COMT” individuals run hot and need different supplement strategies than “fast COMT” individuals. GAD variants affect GABA production and baseline anxiety levels. Detoxification variants affect how you handle hormones, environmental toxins, and even some supplements.
Without genetic data, mental health protocols are educated guesses. With it, they’re personalized. Functional medicine for mental health is an emerging specialty, and genetic testing is one of the foundations — drawing on the Institute for Functional Medicine’s mental health framework alongside the latest pharmacogenomics and nutrigenomics research.
Your Blueprint Report shapes nearly every supplement and dietary recommendation in your protocol. Methylation variants determine which form of folate (folic acid, folinic acid, or methylfolate) and B12 (cyanocobalamin vs. methylcobalamin) are right for you. COMT status guides how aggressively to introduce methyl donors and how to think about catecholamine support. GST and detox variants inform liver-support strategies and determine how cautiously to introduce strong detoxification protocols. Pharmacogenomic variants inform conversations with your prescriber about medication choice and dosing.
Genetics doesn’t change your destiny — but it absolutely changes your protocol. A “slow COMT” individual on high-dose methylfolate will often feel worse before better. A “fast COMT” individual may need significantly more methylation support. The data prevents costly trial and error.
3×4 Genetics is one of seven tests in our standard mental health bundle. It works alongside comprehensive blood biomarkers, DUTCH hormone testing, advanced nutrient analysis, gut microbiome assessment, and food sensitivity testing.
If you've already done genetic testing — 3x4, GeneSight, IntellxxDNA, even raw 23andMe data — bring it. Genetic data is one of the few biomarkers that doesn't change over time, so prior results can be analyzed alongside our program testing to build a fuller picture.
3x4 Genetics is valuable for nearly anyone seeking precision in their mental health protocol, but especially for:
3×4 Genetics is included in our functional medicine assessment and consultation program. Full structure: